Study of the Role of Anti–Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues

The intermolecular forces between anti–cancer molecules such as Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, Lobaplatin, Heptaplatin, Dicycloplatin, Eleutherobin, Epothilone B, Discodermolide and Taxol (Figures 1 and 2) and tumor multiple organs or tissues are of great importance in many areas of science including medicine, chemotherapy, pharmacology, medicinal chemistry, pharmaceutical chemistry, biochemistry and so on [1–21]. As a result, these molecular systems have received a great significant of attention in both computational and theoretical aspects [22–32]. In this commentary, all calculations are carried out by Gaussian 09. Geometry optimization for each molecule are be fulfilled at HF, PM3, MM2, MM3, AM1, MP2, MP3, MP4, CCSD, CCSD(T), LDA, BVWN, BLYP and B3LYP computational methods with 31G, 6– 31G*, 6–31+G*, 6–31G(3df, 3pd), 6–311G, 6–311G* and 6– 311+G* basis sets, respectively. It should be noted that calculations are accomplished at 298 K and 0 K at HF, PM3, MM2, MM3, AM1, MP2, MP3, MP4, CCSD, CCSD(T), LDA, BVWN, BLYP and B3LYP computational methods with 31G, 6– 31G*, 6–31+G*, 6–31G(3df, 3pd), 6–311G, 6–311G* and 6– 311+G* basis sets, respectively. Also, the spectroscopic, structural and thermodynamic properties were investigated.